Chiral, polymorphic and stoichiometric selectivity in the continuous production of multi-component targets

• Main Author: Cousen, Alexander
• Format: Dissertation
• Language: English
• Published: University of Bath 2018

The work outlined in this thesis explores the development of multi-component crystalline materials, in terms of the methods used for their preparation and how these materials can be applied so as to exploit their physicochemical properties. Focussing on co-crystals and salts, by combining two molecular entities within the same crystal lattice, the resultant multi-component system can present a different structure and, therefore, different physical attributes when compared to the starting materials. In many cases, these changes are beneficial, with implications for properties such as solubility, melting point and resolution processes. Like with many crystalline forms, multi-component materials can demonstrate structural variations. Here, these can manifest as either polymorphic, stoichiometric or enantiomeric variants, with the possibility of accessing each form depending upon the crystallisation conditions used. As such, each preparative method is reliant on the composition of material used and the kinetic parameters governing the process. These concepts, examples thereof and the methods of analysis used are detailed in Chapters 1-3.