The synthesis and pharmacology of some novel excitatory amino acid analogues

Certain amino acids, notably L-glutamate and L-aspartate, are believed to fulfil a role as excitatory neurotransmitters in the mammalian Central Nervous System (CNS). Investigation has revealed the presence of three, and possibly a fourth, type of receptor for such neurotransmitters. These receptors...

Full description

Saved in:
Bibliographic Details
Main Author Badman, G. T
Format Dissertation
LanguageEnglish
Published City of London Polytechnic 1986
Subjects
540 Chemistry & allied sciences
610 Medicine & health
Online AccessGet full text

Cover

More Information
Summary:Certain amino acids, notably L-glutamate and L-aspartate, are believed to fulfil a role as excitatory neurotransmitters in the mammalian Central Nervous System (CNS). Investigation has revealed the presence of three, and possibly a fourth, type of receptor for such neurotransmitters. These receptors have been named after the most potent and selective agonist of each; thus they are usually referred to as N-methyl-D-aspartate (A1), quisqualate (A2), kainate (A3) and 2-amino, 4-phosphono butyric acid (A4); the designations in brackets being that of the nomenclature of Fagg and Foster.
Bibliography:0000000134351341