Serum Levels of IL-10 before and after blood donation

Introduction: IL-10 is an anti-inflammatory cytokine produced by Th2 lymphocytes and macrophages and exerts its action on T cells, NK cells and macrophages. Objective: To determine serum levels of interleukin 10 (IL-10) before and after blood donation. Materials and Methods: The sample consisted of...

Full description

Saved in:
Bibliographic Details
Published inVitae academia biomédica digital no. 42
Main Authors Rincón, Maczy González, Medina, Ana Ruiz, Vizcaino, Melvis Arteaga, Troconis, Maribel Quintero, Briceño, Olga, Argüello, Liznelsi, Alvarez, Anya, Anselmi, Jéssica Villasmil
Format Journal Article
Published Venezuela Centro de Análisis de Imágenes Biomédicas Computarizadas-CAIBC0 04.05.2011
Subjects
blood donors
donantes de sangre
IL-10
inmune system
sistema inmunitario
Online AccessGet full text

Cover

More Information
Summary:Introduction: IL-10 is an anti-inflammatory cytokine produced by Th2 lymphocytes and macrophages and exerts its action on T cells, NK cells and macrophages. Objective: To determine serum levels of interleukin 10 (IL-10) before and after blood donation. Materials and Methods: The sample consisted of 20 blood donors of both sexes, between 18 to 60 years of age. Serum concentrations of IL-10 were determined before blood donation, 24 hours afterwards and 12 days after blood donation, using enzyme immunoassay (ELISA). Results: The average serum concentrations of IL-10 were: before donation 12.63 pg / mL, 13.86 pg / mL 4.88 pg / mL 24 hours and 12 days after blood donation respectively. There were not statistically significant differences (p> 0.05) in each study group. Conclusions: No significant changes were found in seric levels of IL10 after blood donation, possibly attributable to the low levels of T cell activation expected in healthy individuals whose immune system is working optimally.
ISSN:1317-987X
1317-987X