Relationship Between Slugging Pressure and Brittle Fracture Tendency - A Case Study for Aspirin Tablets

• Published in: Tropical journal of pharmaceutical research Vol. 4; no. 2
• Main Author: FE Eichie, RS Okor, MU Uhumwangho and IY Osakue
• Format: Journal Article
• Published: Nigeria Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria 22.11.2006
• Subjects: aspirin granules; brittle fracture index; Slugging pressure; tablet tensile strength

Objective - Slugging is a pre-compression technique for the dry granulation of hydrolysable drugs (e.g. aspirin). The study was carried out to relate the slugging load to the hardness of the granules and the brittle fracture tendency of the final (recompressed) tablets. Method - Varying compression...