Relationship Between Slugging Pressure and Brittle Fracture Tendency - A Case Study for Aspirin Tablets
Objective - Slugging is a pre-compression technique for the dry granulation of hydrolysable drugs (e.g. aspirin). The study was carried out to relate the slugging load to the hardness of the granules and the brittle fracture tendency of the final (recompressed) tablets. Method - Varying compression...
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Published in | Tropical journal of pharmaceutical research Vol. 4; no. 2 |
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Main Author | |
Format | Journal Article |
Published |
Nigeria
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
22.11.2006
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Subjects | |
Online Access | Get full text |
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Summary: | Objective - Slugging is a pre-compression technique for the dry
granulation of hydrolysable drugs (e.g. aspirin). The study was carried
out to relate the slugging load to the hardness of the granules and the
brittle fracture tendency of the final (recompressed) tablets. Method
- Varying compression load were applied to aspirin powder to form
slugs, which were subsequently broken down to form granules. These were
recompressed to give the final tablets. The hardness of the slugs was
determined and taken as measure of the hardness of the resulting
granules. The following tableting parameters were measured for the
final tablets - tensile strength (T), packing fraction (Pf) and the
brittle fracture index (BFI). Results - A high slugging load was
associated with the formation of hard slugs and hence hard granules.
Upon recompression the hardest granules formed the hardest tablets (T =
3.29MN m-2) while the softest granules formed the softest tablets
(T=1.09MN m-2). In turn, the hardest tablets displayed the highest
brittle fracture tendency (BFI = 0.59) compared with the softest
tablets (BFI= 0.21). A positive linear correlation existed between
tablet hardness (T) and BFI values (r = 0.98). Conclusion - The study
showed that excessive slugging load produces hard aspirin granules
which in turn yields hard but friable tablets. |
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ISSN: | 1596-5996 1596-5996 |