Enalapril induced severe hyponatremia and altered sensorium in a child

Enalapril is an angiotensin converting enzyme inhibitor widely used in children for treatment of hypertension and congestive cardiac failure. We report a 5-year-old boy who developed severe hyponatremia and altered sensorium on enalapril therapy. The serum sodium gradually became normal within 3 day...

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Bibliographic Details
Published inIndian journal of pharmacology Vol. 43; no. 5
Main Authors Zaki, Syed Ahmed, Bhongade, Swapnil, Shanbag, Preeti
Format Journal Article
Published India Medknow Publications on behalf of Indian Pharmacological Society 15.03.2012
Subjects
Enalapril
hyponatremia
renin angiotensin system
syndrome of inappropriate antidiuretic hormone
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Summary:Enalapril is an angiotensin converting enzyme inhibitor widely used in children for treatment of hypertension and congestive cardiac failure. We report a 5-year-old boy who developed severe hyponatremia and altered sensorium on enalapril therapy. The serum sodium gradually became normal within 3 days. The patient's sensorium improved significantly on correction of hyponatremia. Through this case, we highlight the importance of monitoring serum sodium in patients on enalapril therapy.
ISSN:0253-7613