The functional role of the alpha-1 adrenergic receptors in cerebral blood flow regulation
Cerebral vasculature is richly innervated by the α-1 adrenergic receptors similar to that of the peripheral vasculature. However, the functional role of the α-1adrenergic receptors in cerebral blood flow (CBF) regulation is yet to be established. The traditional thinking being that during normotensi...
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Published in | Indian journal of pharmacology Vol. 43; no. 5 |
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Main Authors | , |
Format | Journal Article |
Published |
India
Medknow Publications on behalf of Indian Pharmacological Society
15.03.2012
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Subjects | |
Online Access | Get full text |
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Summary: | Cerebral vasculature is richly innervated by the α-1 adrenergic
receptors similar to that of the peripheral vasculature. However, the
functional role of the α-1adrenergic receptors in cerebral blood
flow (CBF) regulation is yet to be established. The traditional
thinking being that during normotension and normocapnia sympathetic
neural activity does not play a significant role in CBF regulation.
Reports in the past have stated that catecholamines do not penetrate
the blood brain barrier (BBB) and therefore only influence cerebral
vessels from outside the BBB and hence, have a limited role in CBF
regulation. However, with the advent of dynamic measurement techniques,
beat-to-beat CBF assessment can be done during dynamic changes in
arterial blood pressure. Several studies in the recent years have
reported a functional role of the α-1adrenergic receptors in CBF
regulation. This review focuses on the recent developments on the role
of the sympathetic nervous system, specifically that of the α-1
adrenergic receptors in CBF regulation. |
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ISSN: | 0253-7613 1998-3751 |