A Retrospective Study of Gastric Cancers in Tehran
Background: Gastric cancer is one of the most common cancers in our country. Recent studies have shown that adenocarcinoma of the cardia and distal stomach has increased in the past 25 years. However demographic data is lacking in this regard. Methods: This study is a retrospective case series study...
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Published in | Medical journal of the Islamic Republic of Iran Vol. 20; no. 2 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Published |
Iran
National Research Centre of Medical Sciences of I.R. IRAN
28.07.2008
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Subjects | |
Online Access | Get full text |
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Summary: | Background: Gastric cancer is one of the most common cancers in our
country. Recent studies have shown that adenocarcinoma of the cardia
and distal stomach has increased in the past 25 years. However
demographic data is lacking in this regard. Methods: This study is a
retrospective case series study. All records from 460 consecutive
patients who were documented pathologically to have gastric cancer and
had been referred for diagnosis and follow-up to a private clinic from
1992 to 2002 in Tehran were evaluated. Results: 71 records were
dismissed due to incomprehensive data. Among 389 remaining records
68.5% were males; mean age was 59.4 years (range 13 to 92 years), 31.1%
of patients were 40 years old or less (which is very high). Also 85%
(331) of patients had adenocarcinoma and 5.9% (23) had lymphoma, 8.1%
(31) had undifferentiated carcinoma while only 1% (4) of cases had
gastrointestinal stromal tumor (GIST). 64% of tumors were located in
the middle part of the stomach, 19% in the lower and 17% in the upper
part. In our study the association between H. pylori and adenocarcinoma
was 23.2% in cases younger than 40 years (P<0.001) and 56% in cases
older than 40 years. Cases with lymphoma had the highest correlation
with H. pylori. There was a significant difference between cancer
pathology and sex (P< 0.001). Conclusion: Our data is somehow in
conflict with the western data. We do not recommend blind H. pylori
eradication based on positive serology (at least in Tehran) and we
suggest conduction of larger multicenter studies in this field in our
country. |
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ISSN: | 1016-1430 |