Review Article - Mitochondrial Diseases: An Overview of Genetics, Pathogenesis, Clinical Features and an Approach to Diagnosis and Treatment

Defects in structures or functions of mitochondria, mainly involving the oxidative phosphorylation, mitochondrial biogenesis and other metabolic pathways have been shown to be associated with a wide spectrum of clinical phenotypes. The ubiquitous nature of mitochondria and their unique genetic featu...

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Bibliographic Details
Published inJournal of postgraduate medicine (Bombay) Vol. 46; no. 3
Main Author Singhal N, Gupta BS, Saigal R, Makkar J, Mathur R
Format Journal Article
Published India Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India 24.02.2003
Subjects
Encephalopathy
Mitochondria
mt DNA
Myopathy
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Summary:Defects in structures or functions of mitochondria, mainly involving the oxidative phosphorylation, mitochondrial biogenesis and other metabolic pathways have been shown to be associated with a wide spectrum of clinical phenotypes. The ubiquitous nature of mitochondria and their unique genetic features contribute to the clinical, biochemical and genetic heterogenecity of mitochondrial diseases. This article focuses on the recent advances in the field of mitochondrial disorders with respect to the consequences for an advanced clinical and genetic diagnostics. In addition, an overview on recently identified genetic defects and their pathogenic molecular mechanisms are given.
ISSN:0022-3859