Is CCR7 a potential target for biologic therapy in psoriasis?: Increased expression of CCR7 in psoriasis vulgaris

• Published in: Indian journal of dermatology, venereology, and leprology Vol. 74; no. 5
• Main Authors: Fan, Xin, Shen, Zhu, Wang, Gang, Liu, Yu Feng
• Format: Journal Article
• Language: English
• Published: Medknow Publications on behalf of The Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) 09.10.2009
• Subjects: CC chemokine receptor 7, Psoriasis, Memory lymphocytes
• ISSN: 0378-6323

Background: Activated T cells present in psoriatic plaques play a key role in the pathogenesis of psoriasis. CCR7 on T cells plays a crucial role in native immune response and formation of secondary lymphoid organ. Aims: To determine whether differential expression and functions of the CCR7 occur in psoriasis patients in China, we examined CCR7 on T cells from normal and psoriasis subjects. Methods: Skin specimens and T cells from 33 patients and 22 healthy controls were analyzed by immunohistology, flow cytometry, and RT-PCR. Results: Patients with psoriasis had a skewed distribution of T lymphocytes, with an increased level of CCR7 + T lymphocytes compared to healthy controls (P < 0.01) By flow cytometry, it was found that CCR7 was selectively, frequently, and functionally expressed on CD4 + (20.5±6.8%)but not on CD8 + (9.5±3.4%) T cells from patients with psoriasis, whereas this phenomenon was not seen in normal subjects. Through RT-PCR it was also found that CCR7 was highly expressed on T cells in patients with psoriasis than in healthy controls in the level of gene. Conclusions: Patients with psoriasis had a skewed distribution of T lymphocytes, with an increased level of CCR7 + T lymphocytes compared to healthy controls. CD4 + CCR7 + T cells had abnormal expression, which might induce protraction and persistence of psoriasis.