Case Report - Hypersensitivity and dose related side effects of phenytoin mimicking critical illness

OBJECTIVE: To describe phenytoin-induced rare hypersensitivity and dose related reactions, emphasizing the importance of early omission of drug to achieve clinical improvement. DESIGN: Case series and review of literature. SETTING: Tertiary level medical intensive care unit. PATIENTS: Three cases, t...

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Bibliographic Details
Published inIndian journal of critical care medicine Vol. 9; no. 1
Main Author Pillai LalithaV, Ambike DhananjayP, Hussainy SM K, Vishwasrao Sunil, Pataskar Satish, Gaikwad MarutiM
Format Journal Article
Published India Medknow Publications on behalf of the Indian Society of Critical Care Medicine 25.01.2006
Subjects
allergic alveolitis
dyskinesia
Phenytoin
Phenytoin hypersensitivity syndrome (PHS)
skin lesion
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Summary:OBJECTIVE: To describe phenytoin-induced rare hypersensitivity and dose related reactions, emphasizing the importance of early omission of drug to achieve clinical improvement. DESIGN: Case series and review of literature. SETTING: Tertiary level medical intensive care unit. PATIENTS: Three cases, two of whom had hypersensitivity reactions and the third had drug-induced dyskinesia. INTERVENTION: Omission of phenytoin and corticosteroid therapy in two cases. RESULTS: Improvement and discharge. CONCLUSION: A high index of suspicion of drug-induced complications is necessary especially when multiple drugs are being administered to critically ill patients.
ISSN:0972-5229