Are tumor cell lineages solely shaped by mechanical forces?
This paper investigates cells proliferation dynamics in small tumor cell aggregates using an individual based model (IBM). The simulation model is designed to study the morphology of the cell population and of the cell lineages as well as the impact of the orientation of the division plane on this m...
Saved in:
Main Authors | , , , , , , |
---|---|
Format | Journal Article |
Language | English |
Published |
20.02.2017
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | This paper investigates cells proliferation dynamics in small tumor cell
aggregates using an individual based model (IBM). The simulation model is
designed to study the morphology of the cell population and of the cell
lineages as well as the impact of the orientation of the division plane on this
morphology. Our IBM model is based on the hypothesis that cells are
incompressible objects that grow in size and divide once a threshold size is
reached, and that newly born cell adhere to the existing cell cluster. We
performed comparisons between the simulation model and experimental data by
using several statistical indicators. The results suggest that the emergence of
particular morphologies can be explained by simple mechanical interactions. |
---|---|
DOI: | 10.48550/arxiv.1702.06192 |