Tardive Dyskinesia Possible Involvement of Free Radicals and Treatment With Vitamin E

A decade ago a hypothesis introduced to explain tardive dyskinesia (TD) implicated free radicals generated secondary to neuroleptic treatment. Since then many preclinical and clinical studies have investigated this possibility. These studies suggest that free radicals are probably involved in the pa...

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Bibliographic Details
Published inSchizophrenia bulletin Vol. 25; no. 4; pp. 731 - 740
Main Authors Elkashef, Ahmed M, Wyatt, Richard Jed
Format Journal Article
LanguageEnglish
Published National Institute of Mental Health
Subjects
free radicals
antioxidants
vitamin E
neurodegeneration
Tardive dyskinesia
neuroleptic
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Summary:A decade ago a hypothesis introduced to explain tardive dyskinesia (TD) implicated free radicals generated secondary to neuroleptic treatment. Since then many preclinical and clinical studies have investigated this possibility. These studies suggest that free radicals are probably involved in the pathogenesis of TD and that vitamin E could be efficacious in its treatment.
ISSN:0586-7614
1745-1701