Naquihexcin A, a S‑Bridged Pyrano­naphtho­quinone Dimer Bearing an Unsaturated Hexuronic Acid Moiety from a Sponge-Derived Streptomyces sp. HDN-10-293

S-Bridged pyranonaphthoquinone dimers, naquihexcins A and B (1 and 2), together with a related analogue (−)-BE-52440A (3) were obtained from the culture of a sponge-derived Streptomyces sp. HDN-10-293. Naquihexcin A (1) bears a rare unsaturated hexuronic acid moiety, and (−)-BE-52440A (3) has been d...

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Published inOrganic letters Vol. 18; no. 14; pp. 3358 - 3361
Main Authors Che, Qian, Tan, Hongsheng, Han, Xiaoning, Zhang, Xiaomin, Gu, Qianqun, Zhu, Tianjiao, Li, Dehai
Format Journal Article
LanguageEnglish
Published American Chemical Society 15.07.2016
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Summary:S-Bridged pyranonaphthoquinone dimers, naquihexcins A and B (1 and 2), together with a related analogue (−)-BE-52440A (3) were obtained from the culture of a sponge-derived Streptomyces sp. HDN-10-293. Naquihexcin A (1) bears a rare unsaturated hexuronic acid moiety, and (−)-BE-52440A (3) has been discovered from natural resources. Compound 3 showed cytotoxicity against NB4 and HL-60 cells, while 1 could inhibit the proliferation of the adriamycin resistant human breast cancer cell line MCF-7 ADM.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b01485