Transverse Aortic Constriction: a Model to Study Heart Failure in Small Animals

• Published in: Manual of Research Techniques in Cardiovascular Medicine pp. 164 - 169
• Main Authors: Verma, Suresh Kumar, Krishnamurthy, Prasanna, Kishore, Raj
• Format: Book Chapter
• Language: English
• Published: Oxford, UK John Wiley & Sons, Ltd 21.02.2014
• Subjects: cardiac hypertrophy; cardiovascular disease; heart failure; surgical procedure; transverse aortic constriction

Limitations of in vitro and chemical (angiotensin II or isoproterenol) infusion systems to mimic cardiac hypertrophy and heart failure conditions necessitate a relevant in vivo physiological model to mimic this disease. The leading strategy to develop hypertrophic heart failure in mice is by constri...