A Novel Recyclable Ni/Cu/Fe Termetallic Nanocatalyst for the Synthesis of Propargylamines through the A3‐Coupling Reactions

• Published in: ChemistrySelect (Weinheim) Vol. 5; no. 1; pp. 18 - 27
• Main Authors: Daryanavard, Marzieh, Ataei, Ali, Sheykhabadi, Parvan Ghaderi, Rafiee, Ezzat, Joshaghani, Mohammad
• Format: Journal Article
• Language: English
• Published: 09.01.2020
• Subjects: A3-coupling reactions; aldehyde; amine; nanocatalyst; propargylamines; terminal alkyne
• ISSN: 2365-6549; 2365-6549
• DOI: 10.1002/slct.201902617

A novel Ni/Cu/Fe nanocatalyst was prepared via a three‐step procedure for the A3‐coupling reaction of an aldehyde, an amine, and a terminal alkyne to synthesize the corresponding propargylamine. Oleic acid was used in the second step to avoid aggregation of CuFe2O4 nanoparticles. The prepared NiO/OA‐CuFe2O4 (Ni/Cu/Fe) was characterized using X‐ray diffraction (XRD), scanning electron microscopy/wavelength dispersive X‐ray (SEM/WDX), particle size analyzer, fourier transform infrared (FT‐IR) and atomic absorption spectroscopy (AAS). A variety of propargylamines was synthesized using a very small amount of this efficient and inexpensive nanocatalyst in toluene as the solvent at 100 °C. Due to high magnetic properties of the prepared catalyst, its isolation and recycle were very easy, and it was used in five repetitive cycles. A new recyclable Ni/Cu/Fe nanocatalyst has been prepared via a three‐step procedure and fully characterized. This nanocatalyst exhibits an outstanding catalytic activity towards an inexpensive and economical protocol for A3‐coupling reaction of the aldehydes, amines, and terminal alkynes to synthesis the corresponding propargylamines.