Remotely Triggered Release from Magnetic Nanoparticles
Multifunctional nanoparticles are multivalent, remotely‐actuated, and imaged non‐invasively. Superparamagnetic nanoparticles transduce external electromagnetic energy to heat, thereby melting oligonucleotide duplexes that act as tunable, heat‐labile tethers to release model drugs in vivo (see figure...
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Published in | Advanced materials (Weinheim) Vol. 19; no. 22; pp. 3932 - 3936 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY‐VCH Verlag
19.11.2007
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Subjects | |
Online Access | Get full text |
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Summary: | Multifunctional nanoparticles are multivalent, remotely‐actuated, and imaged non‐invasively. Superparamagnetic nanoparticles transduce external electromagnetic energy to heat, thereby melting oligonucleotide duplexes that act as tunable, heat‐labile tethers to release model drugs in vivo (see figure). |
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Bibliography: | The authors thank Miriam Scadeng for MR imaging and acknowledge financial support of the David and Lucile Packard Foundation, the National Cancer Institute of the National Institutes of Health (N01‐C0‐37117, U54 CA119349‐01, U54 CA119335, 1 R01 CA124427‐01). AMD thanks the UC Biotechnology Research and Education Program for a G.R.E.A.T. fellowship (#2004‐16). The authors declare no competing financial interests. |
ISSN: | 0935-9648 1521-4095 |
DOI: | 10.1002/adma.200700091 |