Remotely Triggered Release from Magnetic Nanoparticles

Multifunctional nanoparticles are multivalent, remotely‐actuated, and imaged non‐invasively. Superparamagnetic nanoparticles transduce external electromagnetic energy to heat, thereby melting oligonucleotide duplexes that act as tunable, heat‐labile tethers to release model drugs in vivo (see figure...

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Bibliographic Details
Published inAdvanced materials (Weinheim) Vol. 19; no. 22; pp. 3932 - 3936
Main Authors Derfus, A. M., von Maltzahn, G., Harris, T. J., Duza, T., Vecchio, K. S., Ruoslahti, E., Bhatia, S. N.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY‐VCH Verlag 19.11.2007
Subjects
Controlled release
Drug delivery
Magnetic nanoparticles
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Summary:Multifunctional nanoparticles are multivalent, remotely‐actuated, and imaged non‐invasively. Superparamagnetic nanoparticles transduce external electromagnetic energy to heat, thereby melting oligonucleotide duplexes that act as tunable, heat‐labile tethers to release model drugs in vivo (see figure).
Bibliography:The authors thank Miriam Scadeng for MR imaging and acknowledge financial support of the David and Lucile Packard Foundation, the National Cancer Institute of the National Institutes of Health (N01‐C0‐37117, U54 CA119349‐01, U54 CA119335, 1 R01 CA124427‐01). AMD thanks the UC Biotechnology Research and Education Program for a G.R.E.A.T. fellowship (#2004‐16). The authors declare no competing financial interests.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200700091