The effects of fenthion on lipid peroxidation and some liver enzymes: The possible protective role of vitamins E and C

• Published in: Turkish journal of medical sciences Vol. 32; no. 4; pp. 293 - 297
• Main Authors: ALTUNTAŞ, İrfan, DELİBAŞ, Namık
• Format: Journal Article
• Language: English
• Published: TÜBİTAK 2002
• Subjects: Ascorbic Acid; Askorbik asit; Büyüme maddeleri, pigmentler ve vitaminler; Cholinesterases; Enzimler; Enzimler, koenzimler ve enzim inhibitörleri; Enzymes; Enzymes, coenzymes and enzyme inhibitors; Fenthion; Fention; Growth substances, pigments and vitamins; Karaciğer; Kolinesterazlar; Lipid peroksidasyonu; Lipid Peroxidation; Liver; Modeller, hayvan; Modeller, teorik; Models, Animal; Models, Theoretical; Organic chemicals; Organik kimyasallar; Rats, Wistar; Sıçan, Wistar; Vitamin E
• ISSN: 1300-0144

The effects of fenthion on the serum activities of cholinesterase (ChE), enzymes concerning liver damage and lipid peroxidation (LPO), and the ameliorating effects of a combination of vitamins E and C against fenthion toxicity were investigated. The results of the in vivo experiment showed that fenthion caused a significant increase in LPO and the activities of aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT) and lactate dehydrogenase (LDH), and a significant decrease in the activities of ChE and alanine aminotransferase (ALT). In addition, treatment with a combination of vitamins E and C led to a significant decrease in LPO and AST activity. In the in vitro experiment, the activity of ChE and ALT were inhibited by fenthion. From these results, it can be concluded that fenthion caused liver damage, and LPO may be one of the molecular mechanisms involved in fenthion-induced toxicity. Vitamins E and C can reduce LPO caused by fenthion.