Effect of dehydration on the pharmacokinetics of mefenamic acid

The pharmacokinetic properties and bioavailability of mefenamic acid was studied in normal and dehydrated rabbits. High perfomance liquid chromatography (HPLC) was used for the assay of mefenamic acid in plasma samples. The mean plasma concentration and area under the plasma concentration-time curve...

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Published inTurkish journal of medical sciences Vol. 29; no. 2; pp. 101 - 104
Main Authors MUZAFFAR, Naeem A, AHMAD, Mahmood, JAMSHAID, Muhammad, BUKHARI, Nadeem I, QAMAR, Shadab
Format Journal Article
LanguageEnglish
Published TÜBİTAK 1999
Subjects
Anti-enflamatuvar ajanlar, steroid olmayan
Anti-Inflammatory Agents, Non-Steroidal
Beslenme ile ilgili ve metabolik hastalıklar
Bioavailability
Biological Availability
Bioyararlanım
Biyolojik yararlanım
Dehydration
Farmakokinetik
Mefenamic Acid
Mefenamik asit
Nutritional and metabolic diseases
Organic chemicals
Organik kimyasallar
Pharmacokinetics
Rabbits
Su kaybı
Tavşanlar
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Summary:The pharmacokinetic properties and bioavailability of mefenamic acid was studied in normal and dehydrated rabbits. High perfomance liquid chromatography (HPLC) was used for the assay of mefenamic acid in plasma samples. The mean plasma concentration and area under the plasma concentration-time curve decreased but the volume of distribution and total body clearance increased significantly (P<0.01) in dehydrated rabbits when compared with normal animals. The results reflect the serious consequences of dehydration on the pharmacokinetics of mefenamic acid.
Bibliography:TTIP
ISSN:1300-0144