Preparation of a Double‐step Modified Carbon Paste Electrode for Trace Quantification of Acyclovir Using TiO2 Nanoparticle and β‐Cyclodextrin

• Published in: Electroanalysis (New York, N.Y.) Vol. 30; no. 12; pp. 2908 - 2915
• Main Authors: Karim‐Nezhad, Ghasem, Khorablou, Zeynab, Mehdikhani, Shabnam
• Format: Journal Article
• Language: English
• Published: 01.12.2018
• Subjects: Acyclovir; Carbon paste electrodes; cyclic voltammetry; TiO2 nanoparticles; β-Cyclodextrin
• ISSN: 1040-0397; 1521-4109
• DOI: 10.1002/elan.201800566

In this work we reported, a simple and reproducible double‐step modified carbon paste electrode (CPE) for recognition and designation of Acyclovir (ACV). In the first stage, for acquiring the structure of TiO2 NPs‐CPE, 5 % TiO2 nanoparticles (NPs) doped into the electrode tissue. In the second stage, β‐Cyclodextrin (β‐CD) anchored on the TiO2 NPs‐CPE surface by electropolymerization which yields a β‐CD/TiO2 NPs‐CPE. Topography, characteristics and electrochemical response of the fabricated electrodes with such techniques as: the field emission scanning electron microscopy (FESEM), chronocoulometry (CC), cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were analyzed. Also the spent TiO2 NPs powders were characterized by X‐ray diffraction (XRD). The results illustrated that this sensor designed efficiently increases the surface area of composite electrode and the performance of the oxidation of ACV at the surface modified electrode compared to the bare electrode improved. Under the desirable situations, the proposed of analytical procedure was proved to be applicable in two linear calibration ranges betwixt 0.09 to 2.98 and 2.98 to 47.61 μM. The detection limit was estimated for low concentrations ACV 21 nM (S/N=3). Eventually, the fabricated composite electrode was successfully applied for the detection of trace amounts of the ACV in the blood serum samples.