Modeling of the Urothelium with an Agent Based Approach

Novel models for cell differentiation and proliferation in the urothelium are presented. The models are simulated with the Glazier-Graner-Hogeweg technique using CompuCell3D. From a variety of tested models, the contact model is the best candidate to explain cell proliferation in the healthy urothel...

Full description

Saved in:
Bibliographic Details
Published inBioinformatics and Biomedical Engineering pp. 375 - 385
Main Authors Torelli, Angelo, Siegel, Fabian, Erben, Philipp, Gumbel, Markus
Format Book Chapter
LanguageEnglish
Published Cham Springer International Publishing 2015
SeriesLecture Notes in Computer Science
Subjects
Agent-based
Glazier-Graner-Hogeweg
Monte Carlo
Simulation
Urothelium
Online AccessGet full text

Cover

More Information
Summary:Novel models for cell differentiation and proliferation in the urothelium are presented. The models are simulated with the Glazier-Graner-Hogeweg technique using CompuCell3D. From a variety of tested models, the contact model is the best candidate to explain cell proliferation in the healthy urothelium. Based on this model, four variations were compared to highlight the key variations that best fit real urothelium. All simulations were quantified by a fitness function designed for the requirements of the urothelium. The findings suggest that adhesion and a nutrient dependent growth may play a crucial role in the maintenance of the urothelium. Aberrations in either adhesion or nutrient dependent growth led to the development of polyp-like formations. This work mimics the regeneration process and the steady state of the urothelium with a spatial and adhesion dependent approach for the first time.
ISBN:9783319164793
3319164791
ISSN:0302-9743
1611-3349
DOI:10.1007/978-3-319-16480-9_37