Microneedle-assisted delivery of NSAIDs

• Published in: CMBEBIH 2017 pp. 311 - 316
• Main Authors: Vranić, E., Tucak, A., Vrabac, Dž., Rahić, O., Elezović, A., Hadžiabdić, J.
• Format: Book Chapter
• Language: English
• Published: Singapore Springer Singapore
• Series: IFMBE Proceedings
• Subjects: Minimally invasive procedures; Nanopatches; Physical enhancement; Transdermal drug delivery
• ISBN: 9811041652; 9789811041655
• ISSN: 1680-0737; 1433-9277
• DOI: 10.1007/978-981-10-4166-2_47

Transdermal drug delivery offers a number of advantages including sustained release, improved patient compliance, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. However, only few medications can be delivered through the transdermal route in therapeutic amounts. NSAIDs are consisted of a group of drugs that are widely used, but their use by oral or transdermal system is limited due to a number of side effects. Therefore, NSAIDs are ideal candidates for delivery via microneedles, a relatively new method of drug delivery. A new concept was introduced known as microneedles and these could be used to effectively deliver drugs using micron-sized needles in a minimally invasive and painless manner. Microneedles can be used to enhance transdermal drug delivery and they can be fabricated in different forms.