Splicing Decisions Shape Neuronal Protein Function across the Transcriptome

Alternative precursor mRNA (pre‐mRNA) splicing diversifies protein modular functions in ways that impact synaptic function and plasticity, as well as the development of neuronal circuitry. Precise control of exon skipping or inclusion comes from the dynamic balance of serine‐arginine (SR), heterogen...

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Bibliographic Details
Published inPosttranscriptional Gene Regulation pp. 163 - 180
Main Authors Dembowski, Jill A, Grabowski, Paula J
Format Book Chapter
LanguageEnglish
Published Weinheim, Germany Wiley‐VCH Verlag GmbH & Co. KGaA 12.06.2013
Subjects
Dscam
hnRNP and KH splicing factors
inducible exons
microRNAs
NMDA R1 receptor
protein modular functions
regulatory networks
splicing codes and signals
synaptic function and plasticity
tissue specificity
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Summary:Alternative precursor mRNA (pre‐mRNA) splicing diversifies protein modular functions in ways that impact synaptic function and plasticity, as well as the development of neuronal circuitry. Precise control of exon skipping or inclusion comes from the dynamic balance of serine‐arginine (SR), heterogeneous ribonucleoprotein (hnRNP), and K‐homology (KH)‐type RNA‐binding proteins and their interactions with cognate RNA motif codes. Here we discuss the mechanisms of alternative splicing events that define neuronal protein functions and highlight the unique properties of splicing factors that confer tissue specificity and developmental control. Extended networks of regulation operate at the posttranscriptional level to modulate splicing factor expression in some cases with the involvement of microRNAs. Genome‐wide approaches used to understand the interplay of RNA splicing codes and factors that coordinate splicing regulation across the transcriptome are also discussed.
ISBN:3527322027
9783527322022
DOI:10.1002/9783527665433.ch7