MicroRNA expression profiles and functions in the brain

R74; MicroRNAs are abundant in the brains of vertebrates and some show a brain-specific or brain-enriched expression pattern. Because microRNAs regulate the expression of hundreds of target genes, it is not surprising that they have profoundly important functions in brain development and pathologica...

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Published in中国神经再生研究（英文版） Vol. 3; no. 12; pp. 1380 - 1385
Main Authors Yanting Qi, Yu Zhao, Zhuyin Chen, Xiaona Chen, Marie C. Lin, Xiangfu Kong, Lihui Lai
Format Journal Article
LanguageEnglish
Published Institute of Molecular and Chemical Biology, East China Normal University, Shanghai 200062, China%Stanley Ho Centre for Emerging Infectious Diseases, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China%Department of Chemistry, Open Laboratory of Chemical Biology, University of Hong Kong, Hong Kong Special Administrative Region, China 01.12.2008
Subjects
neurogenesis
synaptic plasticity
epigenetic control
neural cell specification
posttranscriptionai regulator
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Summary:R74; MicroRNAs are abundant in the brains of vertebrates and some show a brain-specific or brain-enriched expression pattern. Because microRNAs regulate the expression of hundreds of target genes, it is not surprising that they have profoundly important functions in brain development and pathological processes. For example, miR-124 plays an important role in inducing and maintaining neuronal identity through targeting at least two anti-neural factors. MicroRNAs have also been implicated in brain disorders, including brain tumors and neurodegenerative diseases. This review aims to present an overview of the expression profiles and functions of microRNAs in the developing brains of vertebrates.
ISSN:1673-5374