Synthesis of N-tosylguanidines by ring cleavage of 1,2-dihydro-2-tosyliminopyrimidines

• Published in: Synthesis (Stuttgart) no. 6; pp. 845 - 848
• Main Authors: Lasri, J, Gonzalez-Rosende, ME, Sepulveda-Arlues, J
• Format: Journal Article
• Language: English
• Published: STUTTGART Thieme Medical Publishers 01.05.2003
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; cleavage; ring opening; HETEROCYCLES; GUANYLATION; AMINES; imines; sulfonamides; INHIBITORS; nucleophilic addition; DERIVATIVES

The present communication discloses a new synthetic method for the preparation of N-tosylguanidines in high yields by ring cleavage of 1,2-dihydro-2-tosyliminopyrimidines with methylamine.