Synthesis of chiral analogues of FTY720 and its phosphate

Efficient and versatile protocols for the synthesis of chiral analogues of the novel immunomodulator FTY720 and its phosphate are described. These synthetic procedures allow for broad structural variation and deliver essential tools to further elucidate FTY720's novel mechanism of action.

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Bibliographic Details
Published inSynthesis (Stuttgart) no. 11; pp. 1667 - 1670
Main Authors Hinterding, K, Cottens, S, Albert, R, Zecri, F, Buehlmayer, PB, Spanka, C, Brinkmann, Nussbaumer, P, Ettmayer, P, Hoegenauer, K, Gray, N, Pan, SF
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.01.2003
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
chiral auxiliaries
PHOSPHITYLATING AGENT
ETHERS
EFFICIENT PHOSPHORYLATION
sphingolipids
drugs
phosphates
stereoselective synthesis
ASYMMETRIC SYNTHESES
IMMUNOSUPPRESSANT
RECEPTORS
SPHINGOSINE 1-PHOSPHATE
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Summary:Efficient and versatile protocols for the synthesis of chiral analogues of the novel immunomodulator FTY720 and its phosphate are described. These synthetic procedures allow for broad structural variation and deliver essential tools to further elucidate FTY720's novel mechanism of action.
ISSN:0039-7881
DOI:10.1055/s-2003-40883