Synthesis of Novel Unsaturated Alkyl Ethers of Racemic Deoxyisopodophyllotoxin as Cytotoxic Agents

O6; A series of isopentenyl-derived unsaturated alkyl ethers 19-31 of racemic deoxyisopodophyllotoxin were designed and synthesized. For comparison, compound 32 with a benzyl group at the same position was also prepared. The cytotoxicities of the synthetic compounds have been screened for six human...

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Published in中国化学快报（英文版） Vol. 17; no. 7; pp. 863 - 866
Main Authors Ju Hong FENG, Hong Xia DING, Yi XIONG, Yuan Jiang PAN, Yong Min ZHANG, Xiao Jiang HAO, Fran(c)oise GU(E)RITTE, Joachim ST(O)CKIGT, Yu ZHAO
Format Journal Article
LanguageEnglish
Published ZJU-ENS Joint Laboratory of Medicinal Chemistry, Zhejiang University, Hangzhou 310031 01.07.2006
Lehrstuhl für Pharmazeutische Biologie, Institut für Pharmazie, Johannes-Gutenberg Universitat Mainz, D-55099%Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031
Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031%ZJU-ENS Joint Laboratory of Medicinal Chemistry, Zhejiang University, Hangzhou 310031%The Key Laboratory of Chemistry of Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550022%Institut de Chimie des Substances Naturelles, CNRS, F-91198 Gif-sur-Yvette, France%Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031
Subjects
synthesis
Deoxyisopodophyllotoxin
cytotoxic agents
unsaturated alkyl ethers
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Summary:O6; A series of isopentenyl-derived unsaturated alkyl ethers 19-31 of racemic deoxyisopodophyllotoxin were designed and synthesized. For comparison, compound 32 with a benzyl group at the same position was also prepared. The cytotoxicities of the synthetic compounds have been screened for six human tumor cell lines such as KB, BEL-7404, A549, Hela, PC-3 and CNE.The results showed that two of them exhibited significant cytotoxicities with their IC50 values on selected cell lines at μmol/L scale.
ISSN:1001-8417