Analysis of Toxin β-N-Oxalyl-α,β-diaminopropionic Acid (β-ODAP),its Isomer α-ODAP and Other Free Amino Acids in Lathyrus sativus

O6; A method has been presented for the simultaneous analysis of neurotoxin β-N-oxalyl-α,β-diaminopropionic acid (β-ODAP) and its non- or low-toxic isomer 0-ODAP as well as other amino acids in Lathyrus sativus extracts after derivatization with para-nitrobenzyloxycarbonyl chloride (PNZ-C1) by rever...

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Published in中国化学快报（英文版） Vol. 16; no. 5; pp. 627 - 630
Main Authors Ze Yi YAN, Cheng Jin JIAO, Fen Min LI, Yong Min LIANG, Zhi Xiao LI
Format Journal Article
LanguageEnglish
Published State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000%School of life science, Lanzhou University, Lanzhou 730000 01.05.2005
Subjects
α-ODAP
homoarginine
β-diaminopropanoic acid
β-N-oxalyl-L-o
HPLC
PNZ-C1
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Summary:O6; A method has been presented for the simultaneous analysis of neurotoxin β-N-oxalyl-α,β-diaminopropionic acid (β-ODAP) and its non- or low-toxic isomer 0-ODAP as well as other amino acids in Lathyrus sativus extracts after derivatization with para-nitrobenzyloxycarbonyl chloride (PNZ-C1) by reversed-phase (C18 column) high performance liquid chromatography(RP-HPLC). Detection limits of isomers were 0.08 μg/mL for both β-, α-ODAP, for homoarginine 0.09 μg/mL at a signal-to-noise ratio of 3:1.
ISSN:1001-8417
1878-5964