Synthesis of 5-Substituted Hexahydro-1H-1, 4-Diazepine Analogues

O6; 5-Substituted hexahydro-1H-1,4-diazepine analogues were synthesized starting from N, N＇-dibenzyl-1, 2-ethylenediamine and methyl 2, 4-dibromide butyrate through nucleophilic substitution, reduction, chlorination, debenzylation and amidation. Bioactivity tests showed that 9a had the highest agoni...

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Published in中国化学快报(英文版) Vol. 12; no. 11; pp. 951 - 954
Main Authors Jing Shan SHEN, Li Jun LEI, Ru Yun JI, Jian Feng LI, Hai Fang MAO
Format Journal Article
LanguageEnglish
Published Shanghai Institute of Materia Medica, Chinese Academy of Sciences,%Shanghai Jahwa Fine Chemicals Co. Ltd 01.11.2001
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Summary:O6; 5-Substituted hexahydro-1H-1,4-diazepine analogues were synthesized starting from N, N＇-dibenzyl-1, 2-ethylenediamine and methyl 2, 4-dibromide butyrate through nucleophilic substitution, reduction, chlorination, debenzylation and amidation. Bioactivity tests showed that 9a had the highest agonist activity.
ISSN:1001-8417
1878-5964