Traditional Chinese medicine "Qing Yi Tang" alleviates oxygen free radical injury in acute necrotizing pancreatitis

• Published in: 世界胃肠病学杂志（英文版） Vol. 4; no. 4; pp. 357 - 359
• Main Authors: LI Zhan-Liang, WU Cheng-Tang, LU Lian-Rong, ZHU Xiao-Feng, XIONG De-Xin
• Format: Journal Article
• Language: English
• Published: 304th Hospital of PLA, Beijing 100037, China%Nanfang Hospital, First Military Medical University, Guangzhou 510515, China 01.08.1998
• Subjects: malonyldiadehyde/analysis; free radicals; superoxide dismutase/analysis; Qing Yi Tang; pancreatitis/therapy
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v4.i4.357

R5; AIM To observe the changes in oxygen free radical (OFR) and the curative effect of traditional Chinese medicine "Qing Yi Tang" in acute necrotizing pancreatitis (ANP).METHODS After induction of ANP by injection of sodium taurocholate into pancreatic duct, 16 dogs were randomly divided into control group and Chinese medicine group. Serum amylase, SOD and MDA were determined on postoperative day 1, 2, 4 and 7. The animals were sacrificed on day 7. SOD and MDA in organs were determined, and pathological changes in pancreas were observed.RESULTS As compared with control group, the serum level of amylase (734U/L vs 2783U/L) and MDA (7.8nmol/ml vs 14.8nmol/ml) in Chinese medicine group were decreased on day 7 (P＜0.05), while SOD increased significantly (281nU/ml vs 55nU/ml, P＜0.01), and similar changes occurred in MDA and SOD in organs, especially in the pancreas; the pathological changes in the pancreas were alleviated as well.CONCLUSION "Qing Yi Tang" is effective in clearing OFRs and alleviating pathological changes in ANP.