Synthesis of new 4-(5-chloro-2-oxo-3H-benzoxazol-3-yl) butanamide derivatives and their analgesic and anti-inflammatory properties

In this preliminary screening study for developing potent analgesic and anti-inflammatory compounds, eight new 4-(5-chloro-2-oxo-3H-benzoxazol-3-yl)butanamide derivatives were synthesized and screened for their analgesic and anti-inflammatory activities as well as gastric ulceration potential in tes...

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Bibliographic Details
Published inTurkish journal of chemistry Vol. 27; no. 4; pp. 467 - 476
Main Authors ŞAHİN, M. Fethi, BANOĞLU, Erden, KÜPELİ, Esra, YEŞİLADA, Erdem, ÜNLÜ, Serdar, GÜLCAN, H. Ozan
Format Journal Article
LanguageEnglish
Published TÜBİTAK 2003
Subjects
2-okzo-3H-benzookzasol
2-oxo-3H-benzoxazole
analgesic
anti-inflammatory action
Antienflamatör etki
Ağrı kesici
COX I
COX II
Element analizi
elemental analysis
infrared spectroscopy
Kızılötesi spektroskopisi
NMR
Organic Chemistry
Organik Kimya
Sentez
synthesis
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Summary:In this preliminary screening study for developing potent analgesic and anti-inflammatory compounds, eight new 4-(5-chloro-2-oxo-3H-benzoxazol-3-yl)butanamide derivatives were synthesized and screened for their analgesic and anti-inflammatory activities as well as gastric ulceration potential in tested animals. Their structures were elucidated by their IR, 1H-NMR and elemental analysis. All of the compounds exhibited high analgesic and anti-inflammatory activities. None of the compounds except compound 2g caused gastric lesions or bleeding in tested animals.
Bibliography:TMUH
ISSN:1300-0527
1303-6130