Synthesis and antinociceptive activity of 2-[(2-oxobenzothiazolin_3-yl)methlyl]-5-aminoalkyl/aryl-1,3,4,-thiadiazole

Ten 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole derivatives were synthesized. The chemical structures of these compounds were elucidated by their FT-IR and $^1H-NMR$ spectral data, as well as their elemental analyses. The compounds were tested for antinociceptive activit...

Full description

Saved in:
Bibliographic Details
Published inTurkish journal of chemistry Vol. 28; no. 4; pp. 461 - 468
Main Authors ÖNKOL, Tijen, YILDIRIM, Engin, ŞAHİN, M. Fethi, EROL, Kevser, ÇAKIR, Bilge
Format Journal Article
LanguageEnglish
Published TÜBİTAK 2004
Online AccessGet full text

Cover

More Information
Summary:Ten 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole derivatives were synthesized. The chemical structures of these compounds were elucidated by their FT-IR and $^1H-NMR$ spectral data, as well as their elemental analyses. The compounds were tested for antinociceptive activity. Among these compounds, 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminomethyl-1,3,4-thiadiazole (5a) was found to be significantly more active than the others and the standards in all the tests.
Bibliography:TMUH
ISSN:1300-0527
1303-6130