Microemulsion technique for the novel synthesis of deferasirox using metal mediated coupling

A novel and efficient synthesis of Deferasirox has been accomplished using transition metal catalyzed sequential cross coupling reactions. First stage of the synthesis employs the use of Chan-Lam coupling between 3,5-dibromo-1H[1,2,4]triazole and (4-(methoxycarbonyl)-phenyl)boronic acid to give meth...

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Bibliographic Details
Published inIndian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 53; no. 5; pp. 610 - 618
Main Authors Roy, Bhairab Nath, Singh, Girij Pal, George, Shaji K., Lathi, Piyush S., Agrawal, Manoj K., Trivedi, Anurag, Mishra, Madhan, Singh, Gajendra
Format Journal Article
LanguageEnglish
Published NEW DELHI COUNCIL SCIENTIFIC & INDUSTRIAL RES 01.05.2014
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Deferasirox
Suzuki coupling
AGENT
metal mediated synthesis
Chan-Lam coupling
ACID
LIGANDS
microemulsion
DERIVATIVES
EFFICIENT
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Summary:A novel and efficient synthesis of Deferasirox has been accomplished using transition metal catalyzed sequential cross coupling reactions. First stage of the synthesis employs the use of Chan-Lam coupling between 3,5-dibromo-1H[1,2,4]triazole and (4-(methoxycarbonyl)-phenyl)boronic acid to give methyl 4-(3,5-dibromo-1H-1,2,4-triazol-1-yl)benzoate which is further elaboarated to Deferasirox by Suzuki-Miyaura coupling with 2-hydroxyphenyl-boronic acid pinacol ester in microemlusion.
ISSN:0376-4699
0019-5103