Synthesis and evaluation of some 1, 4-dihydropyridine and their derivatives as antihypertensive agents

A series of 1, 4-dihydro-2, 6-dimethyl-4-{4-[3-(2-aminopyrazine/1-amino-4-methyl piperazine)-2-hydroxy propoxy]phenyl}-pyridine-3, 5-carbamoyl have been synthesized and the structure of the compounds have been confirmed by IR, H-1 NMR, MS & elemental analysis. The title compounds have been evalu...

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Published inIndian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 46; no. 4; pp. 698 - 701
Main Authors Pattan, Shashikant R., Rasal, V. P., Venkatramana, N. V., Khade, A. B., Butle, S. R., Jadhav, S. G., Desai, B. G., Manvi, F. V.
Format Journal Article
LanguageEnglish
Published NEW DELHI NATL INST SCIENCE COMMUNICATION 01.04.2007
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
antimicrobial
anti-tumour
antidiabetic
antihypertensive
vasodilators
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Summary:A series of 1, 4-dihydro-2, 6-dimethyl-4-{4-[3-(2-aminopyrazine/1-amino-4-methyl piperazine)-2-hydroxy propoxy]phenyl}-pyridine-3, 5-carbamoyl have been synthesized and the structure of the compounds have been confirmed by IR, H-1 NMR, MS & elemental analysis. The title compounds have been evaluated for antihypertensive activity by tail-cuff method. Some of these compounds have been found to exhibit excellent anti hypertensive activity.
ISSN:0376-4699