Palladium-Catalyzed Oxidative sp(2) C-H Bond Acylation with Aldehydes

An efficient method was developed for the direct acylation of arene sp(2) C-H bonds with aldehydes using palladium acetate as catalyst and peroxide as oxidant. The solvent-free oxidative acylation reaction assisted by a pyridine directing group provides an easy access to aromatic, aliphatic, and opt...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 352; no. 7; pp. 1145 - 1149
Main Authors Basle, Olivier, Bidange, Johan, Shuai, Qi, Li, Chao-Jun
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 03.05.2010
Subjects
Chemistry
Chemistry, Applied
Chemistry, Organic
Physical Sciences
Science & Technology
palladium catalysis
DECARBONYLATION
DIRECT ARYLATION
ACTIVATIONS
ALKYLATION
C-H functionalization
acylation
FUNCTIONALIZATION
OXYGEN
KETONES
oxidative cross-coupling
CHLORIDES
GLYCINE DERIVATIVES
aliphatic aldehydes
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Summary:An efficient method was developed for the direct acylation of arene sp(2) C-H bonds with aldehydes using palladium acetate as catalyst and peroxide as oxidant. The solvent-free oxidative acylation reaction assisted by a pyridine directing group provides an easy access to aromatic, aliphatic, and optical active ketones.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200900874