Environmentally benign aqueous zinc tetrafluoroborate-catalyzed one-pot Biginelli condensation at room temperature

A trace amount (0.6 mole % with respect to aldehyde or 1,3-dicarbonyl compound) of an aqueous solution of zinc tetrafluoroborate has been used as a mild, efficient and almost neutral catalyst for a one-pot three component condensation of aldehydes, 1,3-dicarbonyl compound and urea or thiourea to aff...

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Bibliographic Details
Published inIndian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 48; no. 3; pp. 408 - 412
Main Authors Kundu, S. K., Majee, A., Hajra, A.
Format Journal Article
LanguageEnglish
Published NEW DELHI Natl Inst Science Communication & Information Resources-Niscair 01.03.2009
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
REVISION
Aqueous zinc tetrafluoroborate
ORGANIC-REACTIONS
EFFICIENT SYNTHESIS
ALDEHYDES
3,4-DIHYDROPYRIMIDIN-2(1H)-ONES
CALCIUM-CHANNEL BLOCKERS
three-component reactions
DIHYDROPYRIMIDINONES
Biginelli condensation
3-COMPONENT
SOLVENT-FREE SYNTHESIS
CHLORIDE
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Summary:A trace amount (0.6 mole % with respect to aldehyde or 1,3-dicarbonyl compound) of an aqueous solution of zinc tetrafluoroborate has been used as a mild, efficient and almost neutral catalyst for a one-pot three component condensation of aldehydes, 1,3-dicarbonyl compound and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2 (1H)-ones (DHPMs) and thiones in high yields at room temperature.
ISSN:0376-4699
0019-5103