An improved procedure of Miyashita protocol for the preparation of ureidomethylene derivatives of 1,3-dicarbonyl compounds

A facile method has been developed for the synthesis of ureidomethylene derivatives by the condensation of 1,3-dicarbonyl compounds, urea and trimethylorthoformate in presence of Zn(OTf)(2) under solvent-free conditions. A variety of 1,3-dicarbonyl compounds undergo this reaction to yield the corres...

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Bibliographic Details
Published inIndian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 53; no. 1; pp. 124 - 126
Main Authors Majee, A., Kundu, S. K., Santra, S., Hajra, A.
Format Journal Article
LanguageEnglish
Published NEW DELHI Natl Inst Science Communication & Information Resources-Niscair 01.01.2014
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
MOLTEN-SALT
MILD
EFFICIENT CATALYST
ORGANOCATALYST
trimethyl orthoformate
solvent-free
1,3-Diones
SOLVENT
INDOLES
urea
zinc triflate
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Summary:A facile method has been developed for the synthesis of ureidomethylene derivatives by the condensation of 1,3-dicarbonyl compounds, urea and trimethylorthoformate in presence of Zn(OTf)(2) under solvent-free conditions. A variety of 1,3-dicarbonyl compounds undergo this reaction to yield the corresponding ureidomethylene derivatives in good yields. Methyl substituted ureas also give the condensation product under similar reaction conditions.
ISSN:0376-4699
0019-5103