An improved procedure of Miyashita protocol for the preparation of ureidomethylene derivatives of 1,3-dicarbonyl compounds
A facile method has been developed for the synthesis of ureidomethylene derivatives by the condensation of 1,3-dicarbonyl compounds, urea and trimethylorthoformate in presence of Zn(OTf)(2) under solvent-free conditions. A variety of 1,3-dicarbonyl compounds undergo this reaction to yield the corres...
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Published in | Indian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 53; no. 1; pp. 124 - 126 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
NEW DELHI
Natl Inst Science Communication & Information Resources-Niscair
01.01.2014
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Subjects | |
Online Access | Get full text |
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Summary: | A facile method has been developed for the synthesis of ureidomethylene derivatives by the condensation of 1,3-dicarbonyl compounds, urea and trimethylorthoformate in presence of Zn(OTf)(2) under solvent-free conditions. A variety of 1,3-dicarbonyl compounds undergo this reaction to yield the corresponding ureidomethylene derivatives in good yields. Methyl substituted ureas also give the condensation product under similar reaction conditions. |
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ISSN: | 0376-4699 0019-5103 |