2,4-Diaminotriazines as anti-infective agents

Triazines are scaffolds of interest to medicinal chemists as they have a wide variety of pharmacological activities. Molecules with the triazine moiety have been explored extensively for their anti-infective potential. In this paper, we report a series of 2,4-diaminotriazine derivatives which have b...

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Bibliographic Details
Published inJournal of the Indian Chemical Society Vol. 97; no. 8; pp. 1211 - 1215
Main Authors De, Suparna S., Vogalu, Siva K., Ansari, Nazima, Patil, Rajendra, Sriram, Dharmarajan, Degani, Mariam S.
Format Journal Article
LanguageEnglish
Published JODHPUR Scientific Publ-India 01.08.2020
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
tuberculosis
BIOLOGICAL EVALUATION
DIHYDROFOLATE-REDUCTASE
2,4-Diaminotriazine
TRIAZINES
INHIBITORS
leishmaniasis
DERIVATIVES
cytotoxicity
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Summary:Triazines are scaffolds of interest to medicinal chemists as they have a wide variety of pharmacological activities. Molecules with the triazine moiety have been explored extensively for their anti-infective potential. In this paper, we report a series of 2,4-diaminotriazine derivatives which have been designed and synthesized to explore their DHFR inhibiting potential in various micro-organisms. These molecules have not only been evaluated for their anti-tuberculosis activity, but also for their E. coli, S. aureus and their anti-leishmanial potential. The series has moderate activity vs E. coli and S. aureus, low activity against tuberculosis and good potential for leishmaniasis, from the preliminary results.
ISSN:0019-4522