TBAI-catalyzed synthesis of alpha-ketoamides via sp(3) C-H radical/radical cross-coupling and domino aerobic oxidation

A TBAI-catalyzed one-pot synthesis of cx-ketoamides via sp(3) C-H radical/radical cross-coupling and domino aerobic oxidation was developed. This synthesis is suitable for abroad range of substrates. The control experiments suggested a possible oxidative coupling mechanism. (C) 2015 Elsevier Ltd. Al...

Full description

Saved in:
Bibliographic Details
Published inTetrahedron letters Vol. 56; no. 31; pp. 4638 - 4641
Main Authors Fan, Weizheng, Shi, Dongyang, Feng, Bainian
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 29.07.2015
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
KETO AMIDE INHIBITORS
ROOM-TEMPERATURE
Radical/radical cross-coupling
Aerobic oxidation
ACETOPHENONES
sp C-H bond
AMIDATION
alpha-Ketoamides
N,N-DIMETHYLFORMAMIDE
AMINES
DERIVATIVES
METAL-FREE
METHYL KETONES
ACCESS
TBAI-catalyzed
Online AccessGet full text

Cover

More Information
Summary:A TBAI-catalyzed one-pot synthesis of cx-ketoamides via sp(3) C-H radical/radical cross-coupling and domino aerobic oxidation was developed. This synthesis is suitable for abroad range of substrates. The control experiments suggested a possible oxidative coupling mechanism. (C) 2015 Elsevier Ltd. All rights reserved.
ISSN:0040-4039
DOI:10.1016/j.tetlet.2015.06.021