Synthesis of novel substituted/unsubstituted-(2,8-bis-trifluoromethyl-quinolin-4-yloxy)-acetic acid: Derivatives of cephalosporin and their antibacterial activity

Substituted/unsubstituted-(2,8-bis-trifluoromethyl-quinolin-4-yloxy)-acetic acid derivatives of cephalosporin have been synthesized by condensation of acid chlorides of substituted/unsubstituted - (2,8-bis-trifluoroi-netliyl-quinolin-4-yloxy)acetic acid with various silylated (6R,7R)-7-amino-3-subst...

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Bibliographic Details
Published inIndian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 45; no. 7; pp. 1734 - 1739
Main Authors Singh, Santosh Kumar, Nahta, Ajay, Tiwari, R. P., Jain, Praveen
Format Journal Article
LanguageEnglish
Published NEW DELHI Natl Inst Science Communication & Information Resources-Niscair 01.07.2006
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
antibacterial activity
hexamethyldisilazane
quinolinoxy acetic acids
ANTIBIOTICS
silylation
substituted cephalosporanic acids
CHEMISTRY
cephalosporins
chlororimethylsilane
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Summary:Substituted/unsubstituted-(2,8-bis-trifluoromethyl-quinolin-4-yloxy)-acetic acid derivatives of cephalosporin have been synthesized by condensation of acid chlorides of substituted/unsubstituted - (2,8-bis-trifluoroi-netliyl-quinolin-4-yloxy)acetic acid with various silylated (6R,7R)-7-amino-3-substituted cephalosporanic acids. The products have been tested for. their antibacterial activity.
ISSN:0376-4699
0019-5103