Synthesis of trypsin inhibitor CMTI-III from squash seeds (Cucurbita maxima) by the application of three different sulfhydryl group protections

Trypsia inhibitor CMTI-III was synthesized by the solid-phase procedure. Fmoc chemistry was applied. Three disulfide bridges were obtained in positions C-16/C-28, C-10/C-22 and C-3/C-20 by the selective removal of different protecting groups and subsequent oxidation.

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Bibliographic Details
Published inPolish journal of chemistry Vol. 70; no. 12; pp. 1522 - 1526
Main Authors Szyk, A, Lesner, A, Rolka, K, Kupryszewski, G
Format Journal Article
LanguageEnglish
Published WARSAW POLISH CHEMICAL SOCIETY 01.12.1996
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
solid phase peptide synthesis
VENOM
OMEGA-CONOTOXIN
AMINO-ACID-SEQUENCE
selective disulfide bridges formation
ANALOGS
VALINE
trypsin inhibitor CMTI-III
CHANNELS
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Summary:Trypsia inhibitor CMTI-III was synthesized by the solid-phase procedure. Fmoc chemistry was applied. Three disulfide bridges were obtained in positions C-16/C-28, C-10/C-22 and C-3/C-20 by the selective removal of different protecting groups and subsequent oxidation.
ISSN:0137-5083