Reductive generation of enolates using a chromium(III) ate-type reagent as a reductant and reactions of the enolates with electrophiles

The chromium ate-type reagent "Bu6CrLi3" reacted cleanly with ketones and esters bearing a leaving group at the alpha -position to produce enolates under mild conditions, where the chromium ate reagent acts as a formal two-electron reductant. In a stepwise manner, the generated enolates re...

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Bibliographic Details
Published inOrganometallics Vol. 20; no. 24; pp. 5014 - 5016
Main Authors Hojo, M, Sakata, K, Ushioda, N, Watanabe, T, Nishikori, H, Hosomi, A
Format Journal Article
LanguageEnglish
Published WASHINGTON Amer Chemical Soc 26.11.2001
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Physical Sciences
Science & Technology
REFORMATSKY REACTION
CHLORIDE
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Summary:The chromium ate-type reagent "Bu6CrLi3" reacted cleanly with ketones and esters bearing a leaving group at the alpha -position to produce enolates under mild conditions, where the chromium ate reagent acts as a formal two-electron reductant. In a stepwise manner, the generated enolates reacted with a variety of electrophiles with high selectivity.
ISSN:0276-7333
1520-6041
DOI:10.1021/om010749y