Synthesis of tertiary p-toluenesulfonamides containing a natural terpenoid 2,6-dimethyl-2,7-octadienyl substituent on the nitrogen atom

Reactions of N-alkyl(or aryl)-N-(2,6-dimethyl-2,7-octadienyl)ami with p-toluenesulfonyl chloride in the presence of aqueous sodium hydroxide lead to formation of N-alkyl(or aryl)-N-(2,6-ditnethyl-2,7-octadienyl)-p-toluenesulfonamides. These products are isomers or isomeric homologs of N-butyl-N-(2,7...

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Published inRussian journal of organic chemistry Vol. 36; no. 7; pp. 996 - 998
Main Authors Petrushkina, EA, Oprunenko, YF
Format Journal Article
LanguageEnglish
Published NEW YORK MAIK NAUKA/INTERPERIODICA 01.07.2000
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
TELOMERIZATION
ISOPRENE
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Summary:Reactions of N-alkyl(or aryl)-N-(2,6-dimethyl-2,7-octadienyl)ami with p-toluenesulfonyl chloride in the presence of aqueous sodium hydroxide lead to formation of N-alkyl(or aryl)-N-(2,6-ditnethyl-2,7-octadienyl)-p-toluenesulfonamides. These products are isomers or isomeric homologs of N-butyl-N-(2,7-dimethyl-2,7-octadienyl)-p-toluenesulfonamide which is an efficient inhibitor of hydroxyl radicals in cytotoxic T-lymphocytes in mice.
ISSN:1070-4280