2-O-substituted-3,6-per-anhydro-alpha-cyclodextrin as potential biocompatible agents for the selective complexation of heavy metal ions with special attention to lead

We report on the synthesis, characterization and ionic complexation properties of hexakis (2-O-acetyl-3,6-anhydro) cyclomaltohexaose and hexakis (2-O-methyl-3,6-anhydro) cyclomaltohexaose using thin-layer chromatography and Nuclear Magnetic Resonance spectroscopy. The selectivity towards cations dep...

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Bibliographic Details
Published inJournal of inclusion phenomena and macrocyclic chemistry Vol. 38; no. 1-4; pp. 287 - 296
Main Authors Baudin, C, Pean, C, Pellizzari, B, Gadelle, A, Fauvelle, F, Debouzy, JC, Dalbiez, JP, Perly, B
Format Journal Article
LanguageEnglish
Published DORDRECHT Springer Nature 01.12.2000
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
hexakis (2-O-acetyl-3,6-anhydro) cyclomaltohexaose
Nuclear Magnetic Resonance
ionic complexation
OCTAKIS(3,6-ANHYDRO)-GAMMA-CYCLODEXTRIN
PER-3,6-ANHYDRO-BETA-CYCLODEXTRIN
CATION-BINDING ABILITY
HEPTAKIS(3,6-ANHYDRO)-BETA-CYCLODEXTRIN
(3,6-anhydro) cyclodextrin
lead
thin-layer chromatography
CHEMICALLY-MODIFIED CYCLODEXTRINS
PER-3,6-ANHYDRO-ALPHA-CYCLODEXTRIN
hexakis (2-O-methyl-3,6-anhydro) cyclomaltohexaose
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Summary:We report on the synthesis, characterization and ionic complexation properties of hexakis (2-O-acetyl-3,6-anhydro) cyclomaltohexaose and hexakis (2-O-methyl-3,6-anhydro) cyclomaltohexaose using thin-layer chromatography and Nuclear Magnetic Resonance spectroscopy. The selectivity towards cations depends on chemical modification of the hydroxyl groups and a very high specificity can be obtained in the case of lead for methylated derivatives.
ISSN:1388-3127
1573-1111
DOI:10.1023/A:1008123610595