Synthesis and hypoglycemic activities of 3-(phthalimidomethyl)-4-substituted-cinnamoyl salicylanilides

3-Phthalimidomethylsalicylic acid (2) was prepared by refluxing N-hydroxymethyl phthalimide (1) with salicylic acid. The corresponding acid chloride (3) was condensed with 4-aminoacetophenone in anhydrous potassium carbonate to give 3-phthalimidomethyl-4-acetylsalicylanilide (4). The salicylanilide...

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Bibliographic Details
Published inJournal of the Indian Chemical Society Vol. 81; no. 3; pp. 258 - 260
Main Authors Sahu, SK, Mishra, SK, Mahapatra, SP, Bhatta, D, Panda, CS
Format Journal Article
LanguageEnglish
Published JODHPUR Scientific Publ-India 01.03.2004
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
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Summary:3-Phthalimidomethylsalicylic acid (2) was prepared by refluxing N-hydroxymethyl phthalimide (1) with salicylic acid. The corresponding acid chloride (3) was condensed with 4-aminoacetophenone in anhydrous potassium carbonate to give 3-phthalimidomethyl-4-acetylsalicylanilide (4). The salicylanilide derivatives (4) were condensed with diverse aromatic aldehydes to afford the title compounds (5). Compounds (5) were screened for their possible hypoglycemic activities.
ISSN:0019-4522