Novel triheterocyclic systems by Mannich reaction on 3-arylsydnones: Synthesis of 3-aryl-4-[2 '-(8 ''-hydroxy-7 ''-quinolinyl-methylamino)-thiazol-4 '-yl]sydnones and 3-aryl-4-[2 '-(3 ''-acryl-2 ''-hydroxy-benzylamino)-thiazol-4 '-yl] sydnones as possible antimicrobial agents

3- Aryl-4 (2'- aminothiazol-4'-yl) sydnones 2a-m when subjected to Mannich reaction with 8-hydroxyquinoline give the triheterocyclic Mannich bases 3a-m. Similar reaction with orthohydroxy acetophenone resulted in the formation of the methylamino derivatives 4 a-m. All these compounds have...

Full description

Saved in:
Bibliographic Details
Published inIndian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 40; no. 8; pp. 742 - 747
Main Authors Mallur, SG, Badami, BV
Format Journal Article
LanguageEnglish
Published NEW DELHI NATL INST SCIENCE COMMUNICATION 01.08.2001
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
BIOLOGICAL INTEREST
Online AccessGet full text

Cover

More Information
Summary:3- Aryl-4 (2'- aminothiazol-4'-yl) sydnones 2a-m when subjected to Mannich reaction with 8-hydroxyquinoline give the triheterocyclic Mannich bases 3a-m. Similar reaction with orthohydroxy acetophenone resulted in the formation of the methylamino derivatives 4 a-m. All these compounds have been evaluated for antimicrobial activity, while compounds 3 a-m have been screened for their antitubercular activity also.
ISSN:0376-4699