Thiazolidinyl-triazinoquinazolines as potent anti-inflammatory agents

Some new 5-(5'-substituted-aryl-2'-oxo-4'-thiazolidin-1'-yl)amino-4-phenyl-2-methyl-10-bromo-[1,2,4]triazino[2,3c]quinazolines have been synthesized by [1,5]cyclocondensation of thiolactic acid with 5-arylidene hydrazino-4-phenyl-2-methyl-10-bromo-[1,2,4] triazino [2,3-c] quinazo...

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Published inIndian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 40; no. 4; pp. 307 - 312
Main Authors Bansal, E, Ram, T, Sharma, S, Tyagi, M, Rani, AP, Bajaj, K, Tyagi, R, Goel, B, Srivastava, VK, Guru, JN, Kumar, A
Format Journal Article
LanguageEnglish
Published NEW DELHI NATL INST SCIENCE COMMUNICATION 01.04.2001
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:Some new 5-(5'-substituted-aryl-2'-oxo-4'-thiazolidin-1'-yl)amino-4-phenyl-2-methyl-10-bromo-[1,2,4]triazino[2,3c]quinazolines have been synthesized by [1,5]cyclocondensation of thiolactic acid with 5-arylidene hydrazino-4-phenyl-2-methyl-10-bromo-[1,2,4] triazino [2,3-c] quinazolines. All the compounds of the series have been screened for their antiinflammatory activity. The most potent compound of the series 5-(5'-p-dimethylaminophenyl-2'-oxo-4'-thiazolidin-1'-yl)amino-4-phenyl-2-methyl-10-bromo-[1,2,4] triazino[2,3-c]quinazolines has shown 48.93% activity at a dose of 50 mg/kg p.o. The structures of the products have been delineated by chemical reactions, elemental analysis and spectral studies.
ISSN:0376-4699