Biotransformations, antibacterial evaluations of the sesquiterpenoids and diterpenoids

Incubation of 6beta,7beta-epoxy-4beta-hydroxyguaian-10-ene 1 with fungus Aspergillus niger affords 4beta,13-dihydroxyguaian-6,10-diene 4 and 4beta,12-dihydroxy-guaian-6,10-diene 5, whereas with a plant pathogenic fungus Glomerella cingulata yields exclusively compound 4. In separate experiments incu...

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Published inIndian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 41; no. 7; pp. 1472 - 1476
Main Authors Rao, MR, Venkatesham, U, Sridevi, KV, Reddy, PS, Jamil, K, Venkateswarlu, Y
Format Journal Article
LanguageEnglish
Published NEW DELHI NATL INST SCIENCE COMMUNICATION 01.07.2002
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
TRANSFORMATION
GLOMERELLA-CINGULATA
BIOCATALYST
SARCOPHYTON
SOFT CORALS
PLANT-PATHOGENIC FUNGUS
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Summary:Incubation of 6beta,7beta-epoxy-4beta-hydroxyguaian-10-ene 1 with fungus Aspergillus niger affords 4beta,13-dihydroxyguaian-6,10-diene 4 and 4beta,12-dihydroxy-guaian-6,10-diene 5, whereas with a plant pathogenic fungus Glomerella cingulata yields exclusively compound 4. In separate experiments incubation of (EEE)-7beta,8beta-epoxy-1-isopropyl-4,8,12-trimethylcyclotetradeca-1,3,11-triene 2 and deoxosarcophine 3 with Aspergillus niger afford exclusively (EEE)-7beta,8alpha-dihydroxy-1-isopropyl-4,8,12-trimethylcyclotetriideca-1,3,1 1-triene 6 and 9beta-hydroxydeoxosarcophine 7, respectively. The structures of compounds 4, 5, 6 and 7 have been confirmed by spectral data. Antibacterial evaluations of these compounds have been conducted.
ISSN:0376-4699