Synthesis of fused sulfonamide (1,1-dioxoisothiazole)substituted 1,5-diarylpyrazoles as cyclooxygenase inhibitors

First synthesis of novel 1,1-dioxo-2,3-dihydrobenzo[d]isothiazolyl substituted 1,5-diarylpyrazoles has been accomplished via oxidative cyclization of 4-fluoro-2-methyl benzenesulfonamide followed by the treatment with hydrazine and then with 1,3-dicarbonyl compounds. A number of 1,5-diarylpyrazoles...

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Bibliographic Details
Published inJournal of the Indian Chemical Society Vol. 80; no. 12; pp. 1095 - 1101
Main Authors Pal, M, Veeramaneni, VR, Kumar, S, Lohray, VB, Yeleswarapu, KR
Format Journal Article
LanguageEnglish
Published JODHPUR Scientific Publ-India 01.12.2003
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
POTENT
COX-2
EFFICACY
SAFETY
ROFECOXIB
SC-58635
OXIDATIVE CYCLIZATION
IDENTIFICATION
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Summary:First synthesis of novel 1,1-dioxo-2,3-dihydrobenzo[d]isothiazolyl substituted 1,5-diarylpyrazoles has been accomplished via oxidative cyclization of 4-fluoro-2-methyl benzenesulfonamide followed by the treatment with hydrazine and then with 1,3-dicarbonyl compounds. A number of 1,5-diarylpyrazoles were synthesized in good yields and some of them were of potential biological interest.
ISSN:0019-4522