Synthetic and mass spectral fragmentation studies on trisubstituted 2H-pyran-2-ones and comparative EIMS behaviour of biologically active 3,5-disubstituted pyrazoles and isoxazoles

Eight 3-cyano-4-thiomethyl-6-aryl-2H-pyran-2-ones 1-8 and three 3-cyano-4-(N,N-dimethyl)amino-6-aryl-2H-pyran-2-ones 9-11 have been synthesised and their detailed mass fragmentation pattern alongwith the X-ray crystal structure of a novel pyrone 5 have been studied. In addition, a comparative EIMS b...

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Published inIndian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry Vol. 36; no. 10; pp. 872 - 879
Main Authors Parmar, VS, Jain, SC, Jha, A, Kumar, N, Kumar, A, Vats, A, Jha, HN, Mukherjee, S, Singh, SK, Jennings, KR, Summerfield, SG, Errington, W, Olsen, CE
Format Journal Article
LanguageEnglish
Published NEW DELHI NATL INST SCIENCE COMMUNICATION 01.10.1997
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
6-ARYL-4-(METHYLTHIO)-2-OXO-2H-PYRAN-3-CARBONITRILES
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Summary:Eight 3-cyano-4-thiomethyl-6-aryl-2H-pyran-2-ones 1-8 and three 3-cyano-4-(N,N-dimethyl)amino-6-aryl-2H-pyran-2-ones 9-11 have been synthesised and their detailed mass fragmentation pattern alongwith the X-ray crystal structure of a novel pyrone 5 have been studied. In addition, a comparative EIMS behaviour of 3,5-disubstituted pyrazoles 16-23 and isoxazoles 12-15 is reported. The pyrazole derivative 23 has been found to possess strong anti-invasive activity against human breast carcinoma cells.
ISSN:0376-4699